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“The FTC review and clearance is required for the deal to be completed and needs more time,” a Roche spokesman said. “The deal is not in doubt at all and we expect it will be completed according to our guidance in the first half of 2019. There needs to be more than 50 percent of the shares to be tendered, but we believe our offer to be full and fair and it has been recommended by the board of Spark,” the spokesman added. Spark shares closed at $114.01 on Tuesday cufflinks shirts zara. Roche shares were down 0.3 percent in early trade..

Gene therapies use specially engineered viruses to deliver genetic material into defective cells, in hopes of improving or potentially even curing an inherited condition. Roche offered more than twice the Philadelphia-based company’s closing price on Feb cufflinks shirts zara. 22 for a portfolio that includes a blindness treatment that has U.S. and European approval and other projects for hemophilia and neurodegenerative disorders such as Huntington’s disease. The offer came as rivals including Novartis also move into gene therapy, where treatments for rare, inherited diseases command some of the highest prices in medicine..

Spark’s blindness therapy Luxturna for instance is priced at $850,000 per patient. The treatment had sales of $27 million in 2018 cufflinks shirts zara. However Spark faces at least three lawsuits in the United States by shareholders challenging the sale, on grounds that it undervalues Spark’s stock and is unfair to shareholders. Roche on Wednesday declined to comment on the lawsuits. Roche Chief Executive Severin Schwan is interested in gene therapies to help compensate for patent losses on his $21 billion per year trio of cancer medicines Rituxan, Herceptin and Avastin, which are facing competition from cheaper copies..

(Reuters) – Venezuela’s state-run energy company, PDVSA, kept oil exports near 1 million barrels per day in March despite U.S. sanctions and power outages that crippled its main export terminal, according to PDVSA documents and Refinitiv Eikon data. The OPEC member stabilized exports in March after shipments fell about 40 percent in February from the prior months, in the immediate aftermath of the United States announcing it would impose sanctions on oil sales to choke off the main source of revenue for socialist President Nicolas Maduro cufflinks shirts zara.

The United States and many Western governments have recognized Venezuelan opposition leader Juan Guaido as the country’s rightful leader cufflinks shirts zara. Guaido in January invoked the constitution to assume an interim presidency on the grounds that Maduro’s 2018 re-election was illegitimate. March’s exports of 980,355 barrels per day (bpd) of crude and fuel were only slightly below February’s shipments of 990,215 bpd, according to the documents seen by Reuters and the Refinitiv Eikon data..